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Reversal of superficial neuromuscular blockade
This drug reverses neuromuscular blockade by antagonizing the effects of neuromuscular blocking agents at the neuromuscular junction.
This drug reverses neuromuscular blockade by antagonizing the effects of neuromuscular blocking agents at the neuromuscular junction. Used for Reversal of superficial neuromuscular blockade induced by neuromuscular blocking agents during general anesthesia.
At a glance
| Generic name | Reversal of superficial neuromuscular blockade |
|---|---|
| Sponsor | Pontificia Universidade Catolica de Sao Paulo |
| Drug class | Neuromuscular blockade reversal agent |
| Target | Acetylcholinesterase or neuromuscular blocking agents (depending on specific agent) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Neuromuscular blocking agents are used during anesthesia to paralyze muscles; reversal agents work by either inhibiting acetylcholinesterase (allowing acetylcholine to accumulate and compete with the blocking agent) or by acting as selective relaxant binding agents that encapsulate and inactivate the blocking drug. This restores neuromuscular transmission and allows spontaneous breathing and muscle function to return.
Approved indications
- Reversal of superficial neuromuscular blockade induced by neuromuscular blocking agents during general anesthesia
Common side effects
- Bradycardia
- Increased salivation
- Muscle fasciculations
- Nausea
Key clinical trials
- The ED95 Dose of Sugammadex to Reverse Rocuronium-Induced Deep Neuromuscular Block Back to Shallow Neuromuscular Block
- Reversal of Moderate or Superficial Neuromuscular Blockade Induced by Cisatracurium (PHASE4)
- Efficacy of Sugammadex in Magnesium Pretreated Patients (PHASE2)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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