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Remifentanil + propofol
Remifentanil is an opioid agonist that provides analgesia and sedation, while propofol is a GABAergic hypnotic agent that induces and maintains anesthesia.
Remifentanil is an opioid agonist that provides analgesia and sedation, while propofol is a GABAergic hypnotic agent that induces and maintains anesthesia. Used for Induction and maintenance of general anesthesia, Sedation and analgesia in mechanically ventilated patients.
At a glance
| Generic name | Remifentanil + propofol |
|---|---|
| Sponsor | Nanfang Hospital, Southern Medical University |
| Drug class | Opioid agonist + GABA-A receptor positive allosteric modulator |
| Target | Mu-opioid receptor (remifentanil); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Remifentanil binds to mu-opioid receptors in the central nervous system to produce rapid-onset analgesia and sedation with ultra-short duration due to rapid ester metabolism. Propofol acts as a positive allosteric modulator of GABA-A receptors, enhancing inhibitory neurotransmission to produce hypnosis and unconsciousness. Together, this combination provides balanced anesthesia with opioid analgesia and hypnotic sedation.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation and analgesia in mechanically ventilated patients
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Muscle rigidity
- Postoperative nausea and vomiting
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio (PHASE4)
- Equivalent MAC in General Anesthesia
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |