Last reviewed 2026-04-22 · How we verify

Remifentanil+Lidocaine

Remifentanil is an opioid agonist that binds mu receptors to provide analgesia and sedation, while lidocaine is a local anesthetic that blocks sodium channels to provide local pain relief.

Remifentanil is an opioid agonist that binds mu receptors to provide analgesia and sedation, while lidocaine is a local anesthetic that blocks sodium channels to provide local pain relief. Used for Intraoperative analgesia and sedation during general anesthesia, Local anesthesia during surgical procedures.

At a glance

Mechanism of action

Remifentanil is a potent synthetic opioid that acts as a mu-opioid receptor agonist, providing rapid-onset analgesia and sedation with quick offset due to rapid metabolism by non-specific plasma esterases. Lidocaine is a local anesthetic that blocks voltage-gated sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. The combination provides both systemic analgesia/sedation and local anesthetic effects.

Approved indications

• Intraoperative analgesia and sedation during general anesthesia
• Local anesthesia during surgical procedures

Common side effects

• Respiratory depression
• Hypotension
• Bradycardia
• Muscle rigidity
• Nausea and vomiting
• Local injection site reactions

Key clinical trials

• The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
• Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
• Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
• Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures (NA)
• Sacral Erector Spinae Plane Block in Transurethral Prostate Resection Surgery (NA)
• Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
• Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
• The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Remifentanil+Lidocaine CI brief — competitive landscape report
• Remifentanil+Lidocaine updates RSS · CI watch RSS
• The First Affiliated Hospital of Zhengzhou University portfolio CI