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Regional analgesia and propofol
Regional analgesia with propofol combines local anesthetic nerve blockade with intravenous sedation to provide perioperative pain control and anxiolysis.
Regional analgesia with propofol combines local anesthetic nerve blockade with intravenous sedation to provide perioperative pain control and anxiolysis. Used for Perioperative analgesia and sedation during surgical procedures.
At a glance
| Generic name | Regional analgesia and propofol |
|---|---|
| Also known as | Regional analgesia |
| Sponsor | The Cleveland Clinic |
| Drug class | Local anesthetic + sedative-hypnotic combination |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology / Perioperative Medicine |
| Phase | Phase 3 |
Mechanism of action
Regional anesthesia techniques (such as peripheral nerve blocks or neuraxial blockade) deliver local anesthetics directly to target nerves to block pain transmission in a specific anatomical region. Propofol is a rapid-acting intravenous sedative-hypnotic that enhances GABAergic inhibition in the central nervous system. Together, this combination approach reduces systemic opioid requirements and provides both local pain relief and conscious sedation during surgical procedures.
Approved indications
- Perioperative analgesia and sedation during surgical procedures
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site reactions
- Transient neurological symptoms (from regional anesthesia)
Key clinical trials
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy. (NA)
- Anterior Quadratus Lumborum Block as a Component of Multimodal Analgesia for Abdominal Hysterectomies (NA)
- SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke (PHASE4)
- Intravenous Sedation and Analgesia Versus Local Anesthesia During Microwave Ablation of Benign Thyroid Nodules (NA)
- Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2 (NA)
- Efficacy of Magnesium Sulfate as an Adjuvant in Erector Spinae Plane Block as an Anesthetic Post Operative After Modified Radical Mastectomy (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Regional analgesia and propofol CI brief — competitive landscape report
- Regional analgesia and propofol updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI