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Rebif New Formulation Titrated

EMD Serono · Phase 3 active Small molecule ✓ Verified May 2026

Rebif New Formulation Titrated is a Interferon Small molecule drug developed by EMD Serono. It is currently in Phase 3 development for Relapsing forms of multiple sclerosis.

Rebif New Formulation Titrated is an interferon beta-1a formulation used to treat multiple sclerosis.

Rebif New Formulation Titrated is used to treat relapsing forms of multiple sclerosis. It is a treatment option for patients with relapsing multiple sclerosis, as indicated by ClinicalTrials.gov.

Likelihood of approval
59.3% vs 58.3% industry baseline
If approved by FDA: likely 2028–2030
Steps remaining: NDA/BLA submission
Confidence: High
Why this estimate
  • Baseline phase 3 → approval rate +58.3pp
    Industry-wide phase 3 drugs reach approval ~58.3% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).
  • Immunology slight uplift +1.0pp
    Mature endpoint landscape (ACR, DAS28, PASI) makes immunology approvals slightly more predictable.
Predicted approval windows by jurisdiction (conditional on FDA approval)
Regulator Country Likely year Lag vs FDA
FDA US 2028–2030
EMA EU 2029–2031 +0.7 yr
MHRA GB 2029–2031 +0.7 yr
Health Canada CA 2029–2032 +0.9 yr
TGA AU 2029–2032 +1.2 yr
PMDA JP 2029–2032 +1.5 yr
NMPA CN 2030–2033 +2.3 yr
MFDS KR 2029–2032 +1.4 yr
CDSCO IN 2029–2033 +1.8 yr
ANVISA BR 2030–2033 +2.3 yr

Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).

Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.

At a glance

Generic nameRebif New Formulation Titrated
SponsorEMD Serono
Drug classInterferon
TargetIFNAR
ModalitySmall molecule
Therapeutic areaImmunology
PhasePhase 3

Mechanism of action

It works by stimulating the body's immune system to reduce inflammation in the central nervous system, thereby slowing the progression of the disease. Interferon beta-1a has been shown to decrease the frequency of relapses and slow the progression of disability in patients with multiple sclerosis.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about Rebif New Formulation Titrated

What is Rebif New Formulation Titrated?

Rebif New Formulation Titrated is a Interferon drug developed by EMD Serono, indicated for Relapsing forms of multiple sclerosis.

How does Rebif New Formulation Titrated work?

Rebif New Formulation Titrated is an interferon beta-1a formulation used to treat multiple sclerosis.

What is Rebif New Formulation Titrated used for?

Rebif New Formulation Titrated is indicated for Relapsing forms of multiple sclerosis.

Who makes Rebif New Formulation Titrated?

Rebif New Formulation Titrated is developed by EMD Serono (see full EMD Serono pipeline at /company/emd-serono).

What drug class is Rebif New Formulation Titrated in?

Rebif New Formulation Titrated belongs to the Interferon class. See all Interferon drugs at /class/interferon.

What development phase is Rebif New Formulation Titrated in?

Rebif New Formulation Titrated is in Phase 3.

What are the side effects of Rebif New Formulation Titrated?

Common side effects of Rebif New Formulation Titrated include Flu-like symptoms, Injection site reactions, Fatigue, Headache, Depression.

What does Rebif New Formulation Titrated target?

Rebif New Formulation Titrated targets IFNAR and is a Interferon.

Related

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing