Last reviewed · How we verify
R-CHOP with doxorubicin
R-CHOP with doxorubicin is a Monoclonal antibody and anthracycline antibiotic Small molecule drug developed by Fondazione Italiana Linfomi - ETS. It is currently in Phase 2 development for Non-Hodgkin lymphoma. Also known as: R-CHOP with doxorubicin analogue, R-COMP.
Rituximab targets CD20 on B cells, doxorubicin is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II.
Rituximab targets CD20 on B cells, doxorubicin is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II. Used for Non-Hodgkin lymphoma.
At a glance
| Generic name | R-CHOP with doxorubicin |
|---|---|
| Also known as | R-CHOP with doxorubicin analogue, R-COMP |
| Sponsor | Fondazione Italiana Linfomi - ETS |
| Drug class | Monoclonal antibody and anthracycline antibiotic |
| Target | CD20 |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Rituximab is a monoclonal antibody that induces direct and antibody-dependent cellular cytotoxicity against B cells expressing CD20. Doxorubicin is a chemotherapeutic agent that intercalates DNA and inhibits topoisomerase II, leading to DNA damage and apoptosis in rapidly dividing cells.
Approved indications
- Non-Hodgkin lymphoma
Common side effects
- Neutropenia
- Anemia
- Thrombocytopenia
- Infection
- Cardiotoxicity
Key clinical trials
- Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma (PHASE3)
- Celecoxib Plus R-CHOP vs R-CHOP in Newly Diagnosed Advanced CD5+ DLBCL (PHASE2)
- Obinutuzumab With or Without Umbralisib, Lenalidomide, or Combination Chemotherapy in Treating Patients With Relapsed or Refractory Grade I-IIIa Follicular Lymphoma (PHASE2)
- Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell Lymphomas (PHASE2, PHASE3)
- Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma (PHASE2)
- A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010) (PHASE3)
- Testing the Addition of an Anti-Cancer Drug, Glofitamab, to the Usual Chemotherapy Treatment (Alternating R-CHOP/R-DHAP) for Previously Untreated Mantle Cell Lymphoma (PHASE1)
- Chidamide Combination With R-mini CHOP Followed by Chidamide+CD20 Maintenance in Elderly Newly Diagnosed MYC/BCL2+ DLBCL (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- R-CHOP with doxorubicin CI brief — competitive landscape report
- R-CHOP with doxorubicin updates RSS · CI watch RSS
- Fondazione Italiana Linfomi - ETS portfolio CI
Frequently asked questions about R-CHOP with doxorubicin
What is R-CHOP with doxorubicin?
How does R-CHOP with doxorubicin work?
What is R-CHOP with doxorubicin used for?
Who makes R-CHOP with doxorubicin?
Is R-CHOP with doxorubicin also known as anything else?
What drug class is R-CHOP with doxorubicin in?
What development phase is R-CHOP with doxorubicin in?
What are the side effects of R-CHOP with doxorubicin?
What does R-CHOP with doxorubicin target?
Related
- Drug class: All Monoclonal antibody and anthracycline antibiotic drugs
- Target: All drugs targeting CD20
- Manufacturer: Fondazione Italiana Linfomi - ETS — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Non-Hodgkin lymphoma
- Also known as: R-CHOP with doxorubicin analogue, R-COMP
- Compare: R-CHOP with doxorubicin vs similar drugs
- Pricing: R-CHOP with doxorubicin cost, discount & access