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Quadrivalent Influenza Vaccine
This vaccine works by stimulating the body's immune system to produce antibodies against influenza viruses.
The Quadrivalent Influenza Vaccine, developed by the International Centre for Diarrhoeal Disease Research, Bangladesh, currently lacks a strong market position due to the absence of clinical trial data and brand recognition. Its mechanism of stimulating the immune system to produce antibodies against influenza viruses is a standard approach, but it faces significant competition from established brands like Tamiflu, Fluzone High-Dose, and Afluria, which offer specific advantages such as targeted efficacy in older adults or alternative treatment methods. A key risk for the vaccine is the lack of clinical trial data, which may hinder its adoption and regulatory approval, especially in markets where PD-L1 companion diagnostics are required for certain indications. The pipeline outlook remains uncertain without ongoing or planned clinical trials to demonstrate efficacy and safety, which are crucial for gaining a competitive edge in the crowded influenza vaccine market.
At a glance
| Generic name | Quadrivalent Influenza Vaccine |
|---|---|
| Also known as | Influvax Tetra Vaccine, GC3110A, VaxigripTetra™, VaxigripTetra®, QIV |
| Sponsor | International Centre for Diarrhoeal Disease Research, Bangladesh |
| Drug class | Inactivated vaccine |
| Target | Influenza viruses |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
Mechanism of action
The Quadrivalent Influenza Vaccine is a type of vaccine that is designed to protect against four different strains of the influenza virus. It contains antigens from two influenza A subtype viruses (A/H1N1 and A/H3N2) and two influenza B viruses. When administered to a person, the vaccine stimulates the body's immune system to produce antibodies against these viruses, providing protection against infection. This is achieved through the activation of immune cells, such as T-cells and B-cells, which recognize and respond to the antigens present in the vaccine.
Approved indications
- Prevention of influenza disease caused by influenza A subtype viruses (A/H1N1, A/H3N2) and influenza B viruses in people 6 months of age and older
- Prevention of influenza disease caused by influenza A subtype viruses (A/H1N1, A/H3N2) and influenza B viruses in people 6 months of age and older, when the circulating influenza A and B viruses are expected to be well matched to the vaccine viruses.
Common side effects
Drug interactions
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Competitive intelligence
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