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Quadratus Lumborum Block (QLB)

University of Alabama at Birmingham · FDA-approved active Small molecule

A regional anesthesia technique that blocks nerve signals in the quadratus lumborum muscle region to provide pain relief for abdominal and flank procedures.

A regional anesthesia technique that blocks nerve signals in the quadratus lumborum muscle region to provide pain relief for abdominal and flank procedures. Used for Perioperative analgesia for abdominal and flank surgery, Postoperative pain management, Chronic pain conditions affecting the lower abdomen and flank.

At a glance

Generic nameQuadratus Lumborum Block (QLB)
Also known asbolus, bupivacaine, epinephrine, aliquots, liposomal bupivacaine
SponsorUniversity of Alabama at Birmingham
ModalitySmall molecule
Therapeutic areaAnesthesia/Pain Management
PhaseFDA-approved

Mechanism of action

The QLB is a peripheral nerve block procedure that delivers local anesthetic to the plane between the quadratus lumborum muscle and the adjacent fascia, blocking sensory innervation to the lower abdomen, flank, and lower back. This technique provides analgesia for surgical procedures and postoperative pain management without systemic effects of general anesthesia.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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