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PUFAs
PUFAs are a class of polyunsaturated fatty acids that modulate inflammation and lipid metabolism.
PUFAs are a class of polyunsaturated fatty acids that modulate inflammation and lipid metabolism. Used for Hypertriglyceridemia, Hypercholesterolemia.
At a glance
| Generic name | PUFAs |
|---|---|
| Sponsor | Federal University of São Paulo |
| Drug class | Fatty acid |
| Target | PPAR-alpha, PPAR-gamma |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular, Metabolic |
| Phase | Phase 3 |
Mechanism of action
PUFAs exert their effects by binding to and activating specific receptors, influencing the production of pro-inflammatory eicosanoids and modulating the activity of various enzymes involved in lipid metabolism.
Approved indications
- Hypertriglyceridemia
- Hypercholesterolemia
Common side effects
- Abdominal pain
- Diarrhea
- Nausea
Key clinical trials
- n-3 Polyunsaturated Fatty Acids to Prevent and Treat Diabetic Neuropathy (NA)
- The Mediterranean Diet Based on Local Foods for Obese Patients (NA)
- Observing Metabolism of EPA With Consideration of Genetics And Sex (PHASE4)
- NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status (NA)
- Omega-3 Supplementation for Pediatric Migraine (NA)
- Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers (NA)
- Study of the Implication of Omega-3 Polyunsaturated Fatty Acids in Retinopathy of Prematurity in New-born Infants (NA)
- Effect of Consuming n-3 PUFAs Rich Foods on Triglyceride Concentration and Lipoprotein Composition (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |