Last reviewed · How we verify
Protamin
At a glance
| Generic name | Protamin |
|---|---|
| Also known as | viscoelastic testing (Clot-Pro), ACT |
| Sponsor | University of Ioannina |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | FDA-approved |
Approved indications
- Heparin overdose
Common side effects
- Hypoglycemia
- Headache
- Influenza-like symptoms
- Upper respiratory tract infection
- Dyspepsia
- Headache
- Diarrhea
- Neuropathy
- Back pain
- Diarrhea
- Pharyngitis
- Pharyngitis
Serious adverse events
- Severe Hypoglycemia
- Severe Hypoglycemia
- Anaphylaxis
- Worsening of diabetic retinopathy
- Acute painful peripheral neuropathy
- Lipodystrophy
- Pruritus
- Erythema
- Edema
- Ophthalmologic refraction disorder
Key clinical trials
- Heparin Based on Ideal Body Weight for Cardiopulmonary Bypass in Obese Patients (PHASE4)
- Heparin Reversal With Two Different Protamine Ratios After Cardiopulmonary By-pass. (NA)
- Adjusted Calculation of Heparin and Protamin Dosing and Correlation With Postoperative Bleeding and Transfusions (PHASE4)
- Peptide-specific Vaccination in HLA-A*02 Positive Patients With Biochemical Recurrence After Radical Prostatectomy (PHASE1, PHASE2)
- The Copenhagen Insulin and Metformin Therapy Trial (PHASE4)
- A Randomised, Single Centre, Double-Blind, Two-Period Crossover, Glucose Clamp Trial (PHASE1)
- Preop Hemodialysis or Intraop Ultrafiltration for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery (PHASE3)
- The Efficacy of Hypertonic Lactate Solution in CABG(Coronary Artery Bypass Grafting) Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |