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Prostin E2
Prostin E2 (dinoprostone) is a prostaglandin E2 analog that binds to prostaglandin E receptors to promote uterine contractions and cervical ripening.
Prostin E2 (dinoprostone) is a prostaglandin E2 analog that binds to prostaglandin E receptors to promote uterine contractions and cervical ripening. Used for Cervical ripening and labor induction in term pregnancy, Management of incomplete or missed abortion.
At a glance
| Generic name | Prostin E2 |
|---|---|
| Also known as | Dinoprostone (PGE2)vaginal tablets. |
| Sponsor | Ain Shams University |
| Drug class | Prostaglandin E2 analog |
| Target | Prostaglandin E receptor (EP receptors) |
| Modality | Small molecule |
| Therapeutic area | Obstetrics |
| Phase | Phase 3 |
Mechanism of action
Dinoprostone mimics the natural prostaglandin E2, activating EP receptors on uterine smooth muscle and cervical tissue. This increases intracellular calcium and promotes myometrial contractions while softening and dilating the cervix. It is used to induce labor or facilitate cervical ripening prior to labor induction.
Approved indications
- Cervical ripening and labor induction in term pregnancy
- Management of incomplete or missed abortion
Common side effects
- Uterine hyperstimulation
- Vaginal bleeding
- Fever
- Nausea and vomiting
- Diarrhea
- Abdominal pain
Key clinical trials
- An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis (PHASE2)
- Effect of Nigella Sativa Toothpaste on Salivary Biomarkers in Patients With Gingivitis (NA)
- Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy (PHASE3)
- PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM) (NA)
- Comparison of Conventional and Cu-NiTi Archwires Regarding Clinical Efficiency and Pain Intensity Using Prostaglandin E2 Biomarker During Alignment and Leveling (NA)
- Evaluation of the Biomechanical Response of Orthodontic Tooth Movement to Clear Aligner vs Fixed Orthodontic Appliance (NA)
- PGE2/IL-22 Pathway in Various Forms of Eczema
- INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |