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Propofol + Remifentanyl
Propofol and remifentanil together provide rapid-onset sedation and analgesia by depressing the central nervous system through GABA potentiation and opioid receptor agonism, respectively.
Propofol and remifentanil together provide rapid-onset sedation and analgesia by depressing the central nervous system through GABA potentiation and opioid receptor agonism, respectively. Used for Induction and maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care settings.
At a glance
| Generic name | Propofol + Remifentanyl |
|---|---|
| Sponsor | Azienda Ospedaliera San Gerardo di Monza |
| Drug class | Intravenous anesthetic combination (hypnotic + opioid) |
| Target | GABA-A receptor (propofol); mu-opioid receptor (remifentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Propofol is an intravenous hypnotic agent that enhances inhibitory GABA-A receptor signaling, producing sedation and unconsciousness. Remifentanil is a potent synthetic opioid agonist that binds mu-opioid receptors to provide rapid analgesia and anxiolysis. The combination is used for balanced anesthesia, allowing lower doses of each agent while achieving synergistic sedative and analgesic effects.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in mechanically ventilated patients in intensive care settings
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Injection site pain
- Apnea
- Muscle rigidity
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio (PHASE4)
- Equivalent MAC in General Anesthesia
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |