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Propofol, Midazolam, and Fentanyl
This is a combination of three sedative and analgesic agents that work together to produce anesthesia, sedation, and pain relief through different mechanisms at the central nervous system.
This is a combination of three sedative and analgesic agents that work together to produce anesthesia, sedation, and pain relief through different mechanisms at the central nervous system. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units, Procedural sedation.
At a glance
| Generic name | Propofol, Midazolam, and Fentanyl |
|---|---|
| Also known as | Diprivan |
| Sponsor | Montefiore Medical Center |
| Drug class | Sedative-hypnotic/opioid combination |
| Target | GABA-A receptor (propofol, midazolam); mu-opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol is a GABA-A receptor agonist that produces sedation and hypnosis. Midazolam is a benzodiazepine that enhances GABA-A receptor activity to provide anxiolysis and sedation. Fentanyl is an opioid mu-receptor agonist that provides analgesia and potentiates sedation. Together, they create balanced anesthesia with sedation, analgesia, and amnesia.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
- Procedural sedation
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Injection site pain (propofol)
- Apnea
- Chest wall rigidity (fentanyl)
Key clinical trials
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction (PHASE4)
- Comparison of Prolotherapy and Rehabilitation Treatments in Low Back Pain (CPRTLBP) (NA)
- Assessment of Endotracheal Tube Temperature Effects in Children Undergoing Adenotonsillectomy (NA)
- Effect of Dexmedetomidine on Tear Production in Angioplasty Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol, Midazolam, and Fentanyl CI brief — competitive landscape report
- Propofol, Midazolam, and Fentanyl updates RSS · CI watch RSS
- Montefiore Medical Center portfolio CI