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Propofol, Lidocaine and fentanyl
This is a combination of three agents that work together: propofol (GABA agonist for sedation), lidocaine (local anesthetic blocking sodium channels), and fentanyl (opioid agonist for analgesia and sedation).
This is a combination of three agents that work together: propofol (GABA agonist for sedation), lidocaine (local anesthetic blocking sodium channels), and fentanyl (opioid agonist for analgesia and sedation). Used for Induction and maintenance of general anesthesia, Sedation for procedures and mechanical ventilation.
At a glance
| Generic name | Propofol, Lidocaine and fentanyl |
|---|---|
| Sponsor | Kasr El Aini Hospital |
| Drug class | Anesthetic combination (sedative-hypnotic, local anesthetic, opioid) |
| Target | GABA-A receptor (propofol), voltage-gated sodium channels (lidocaine), mu-opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology / Sedation |
| Phase | FDA-approved |
Mechanism of action
Propofol enhances inhibitory GABAergic neurotransmission to produce rapid sedation and hypnosis. Lidocaine blocks voltage-gated sodium channels to provide local anesthetic effects and reduce pain perception. Fentanyl binds to mu-opioid receptors to provide analgesia, anxiolysis, and potentiate sedation. Together, these agents provide balanced anesthesia with sedation, analgesia, and amnesia.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation for procedures and mechanical ventilation
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain (propofol)
- Apnea
- Chest wall rigidity (fentanyl)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
- Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy (PHASE4)
- Comparison of Airway Management With Bronchial Blocker and Double-Lumen Tube in Single-Lung Ventilation (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Transition From Acute to Chronic Opioid Use and Chronic Pain (EARLY_PHASE1)
- Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol, Lidocaine and fentanyl CI brief — competitive landscape report
- Propofol, Lidocaine and fentanyl updates RSS · CI watch RSS
- Kasr El Aini Hospital portfolio CI