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Propofol Injection
Propofol is a rapid-acting intravenous sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system.
Propofol is a rapid-acting intravenous sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system. Used for Induction of general anesthesia, Maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units.
At a glance
| Generic name | Propofol Injection |
|---|---|
| Also known as | intravenous anesthesia, Total intravenous anesthesia, active comparator, 2,6-diisopropylphenol; Diprivan, P Group |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Drug class | Intravenous sedative-hypnotic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization, leading to sedation and unconsciousness. It has a rapid onset (within seconds) and short duration of action due to rapid redistribution and metabolism, making it ideal for induction and maintenance of anesthesia.
Approved indications
- Induction of general anesthesia
- Maintenance of general anesthesia
- Sedation in mechanically ventilated patients in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Pain on injection
- Apnea
- Propofol infusion syndrome (with prolonged high-dose infusion)
Key clinical trials
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Study Comparing Local/ MAC Anesthesia in Lumbar Decompression (EARLY_PHASE1)
- Propofol vs Remifentanil for Sedation in Gastroscopy (NA)
- Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
- Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users (PHASE1)
- Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain (NA)
- A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients (PHASE2, PHASE3)
- Comparison of Prolotherapy and Rehabilitation Treatments in Low Back Pain (CPRTLBP) (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |