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Propofol (Group P)
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system, leading to rapid onset of unconsciousness.
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system, leading to rapid onset of unconsciousness. Used for Induction and maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units.
At a glance
| Generic name | Propofol (Group P) |
|---|---|
| Also known as | Comparator |
| Sponsor | All India Institute of Medical Sciences |
| Drug class | Sedative-hypnotic, intravenous anesthetic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing the frequency and duration of chloride channel opening. This hyperpolarizes neuronal membranes and suppresses neuronal firing, producing rapid sedation and anesthesia. It has a very short duration of action due to rapid redistribution and metabolism.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in mechanically ventilated patients in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
- Propofol infusion syndrome (with prolonged high-dose infusion)
Key clinical trials
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy
- Cognitive Function in Geriatric Colonoscopy Patients
- Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter (PHASE4)
- The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction (PHASE4)
- Procedural Sedation in Renal Sympathetic Denervation
- The Effect of Propofol Versus Lidocaine on Emergence Agitation in Children Undergoing Tonsillectomy. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol (Group P) CI brief — competitive landscape report
- Propofol (Group P) updates RSS · CI watch RSS
- All India Institute of Medical Sciences portfolio CI