Last reviewed · How we verify
Propofol based general anesthesia
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system to produce rapid unconsciousness and anesthesia.
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system to produce rapid unconsciousness and anesthesia. Used for Induction and maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units.
At a glance
| Generic name | Propofol based general anesthesia |
|---|---|
| Also known as | Control |
| Sponsor | The First Affiliated Hospital of Anhui Medical University |
| Drug class | Sedative-hypnotic; GABA-A receptor positive allosteric modulator |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization. This results in depression of the central nervous system, producing sedation, hypnosis, and anesthesia. It has rapid onset and offset due to its lipophilic properties and quick redistribution from the brain.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in mechanically ventilated patients in intensive care units
Common side effects
- Hypotension
- Apnea
- Bradycardia
- Injection site pain
- Headache
- Propofol infusion syndrome (with prolonged high-dose infusion)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) (NA)
- Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: