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Propofol as induction agent
Propofol is a rapid-acting intravenous sedative-hypnotic that enhances inhibitory GABA neurotransmission in the central nervous system to induce unconsciousness.
Propofol is a rapid-acting intravenous sedative-hypnotic that enhances inhibitory GABA neurotransmission in the central nervous system to induce unconsciousness. Used for Induction of general anesthesia in adults and children, Sedation during mechanical ventilation in intensive care settings, Sedation for diagnostic and therapeutic procedures.
At a glance
| Generic name | Propofol as induction agent |
|---|---|
| Sponsor | Fayoum University Hospital |
| Drug class | Intravenous sedative-hypnotic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization. This results in rapid onset of sedation and unconsciousness suitable for anesthesia induction. The drug has a short duration of action due to rapid redistribution and metabolism.
Approved indications
- Induction of general anesthesia in adults and children
- Sedation during mechanical ventilation in intensive care settings
- Sedation for diagnostic and therapeutic procedures
Common side effects
- Hypotension
- Respiratory depression
- Injection site pain
- Bradycardia
- Apnea
- Headache
- Propofol infusion syndrome (with prolonged use)
Key clinical trials
- Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP (PHASE4)
- Comparing Inhalation and Total Intravenous Anesthesia Methods
- Efficacy and Safety of Anricofen Combined With Ciprofol for Deep Sedation in Elderly Patients Undergoing ERCP (NA)
- Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrectomy (NA)
- A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery (PHASE4)
- Effect of Nalbuphine on Hemodynamic Response During Laryngoscopy and Intubation (NA)
- Comparison of the Effects of Total Intravenous Anaesthesia With Target-Controlled Infusion (TCI) and Inhalation Anaesthesia on Airway Complications During Extubation and in the Early Postoperative Period in Thyroidectomy Surgery (NA)
- Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol as induction agent CI brief — competitive landscape report
- Propofol as induction agent updates RSS · CI watch RSS
- Fayoum University Hospital portfolio CI