Last reviewed · How we verify
propofol and isoflurane
Propofol and isoflurane are intravenous and inhaled anesthetic agents that enhance inhibitory GABAergic neurotransmission and suppress excitatory glutamatergic signaling to produce sedation, hypnosis, and anesthesia.
Propofol and isoflurane are intravenous and inhaled anesthetic agents that enhance inhibitory GABAergic neurotransmission and suppress excitatory glutamatergic signaling to produce sedation, hypnosis, and anesthesia. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units, Procedural sedation.
At a glance
| Generic name | propofol and isoflurane |
|---|---|
| Also known as | Diprivan, isoflurane |
| Sponsor | University Hospitals Bristol and Weston NHS Foundation Trust |
| Drug class | General anesthetic agents |
| Target | GABA-A receptor; NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol is an intravenous sedative-hypnotic that potentiates GABA-A receptor activity, leading to central nervous system depression. Isoflurane is a volatile inhaled anesthetic with similar GABAergic mechanisms and additional effects on ion channels. Together or individually, they are used to induce and maintain general anesthesia by depressing the central nervous system.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
- Procedural sedation
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain (propofol)
- Postoperative nausea and vomiting
- Emergence delirium
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2) (PHASE3)
- Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1) (PHASE3)
- Comparison of Two Sedative Agents in Terms of Controlled Hypotension (NA)
- Reduction of Muscle Catabolism Through Brain Activation in Burn Patients (NA)
- Effect of Position and Anesthetic Choice in Intraocular Pressure in Robotic GYN (Gynecologic) Oncology Patients (PHASE4)
- Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy. (NA)
- Total Intravenous Anesthesia (TIVA) Versus Inhalational Anesthesia at The End of Laparoscopic Obstetric Surgery Regarding Postoperative Nausea and Vomiting (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: