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Propofol alone
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system, leading to rapid loss of consciousness.
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system, leading to rapid loss of consciousness. Used for Induction and maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units, Sedation for diagnostic and therapeutic procedures.
At a glance
| Generic name | Propofol alone |
|---|---|
| Also known as | Diprivan, Propofol, 2,6-di-isopropofol |
| Sponsor | Lions Gate Hospital |
| Drug class | Sedative-hypnotic; GABA-A receptor positive allosteric modulator |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia; Critical Care |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing the frequency and duration of chloride channel opening. This hyperpolarizes neuronal membranes and suppresses neuronal firing, producing rapid sedation and anesthesia. It is commonly used for induction and maintenance of general anesthesia and for sedation in critical care settings.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in mechanically ventilated patients in intensive care units
- Sedation for diagnostic and therapeutic procedures
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
- Propofol infusion syndrome (with prolonged use)
Key clinical trials
- Anesthesia-Masked Psilocybin Therapy for Major Depression (PHASE2)
- Treatment Response In ECT Patients
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- The Impact of Anesthetics on FLIP (NA)
- Propofol vs Remifentanil for Sedation in Gastroscopy (NA)
- Comparison of Airway Management With Bronchial Blocker and Double-Lumen Tube in Single-Lung Ventilation (NA)
- Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |