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Propofol + Alfentanil
Propofol and alfentanil together provide rapid induction and maintenance of general anesthesia through synergistic central nervous system depression.
Propofol and alfentanil together provide rapid induction and maintenance of general anesthesia through synergistic central nervous system depression. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units.
At a glance
| Generic name | Propofol + Alfentanil |
|---|---|
| Sponsor | Region Jönköping County |
| Drug class | Intravenous anesthetic combination (hypnotic + opioid) |
| Target | GABA-A receptor (propofol); mu-opioid receptor (alfentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol is an intravenous hypnotic agent that enhances GABAergic inhibitory neurotransmission in the central nervous system, inducing unconsciousness. Alfentanil is a potent synthetic opioid agonist at mu-opioid receptors that provides analgesia and enhances sedation. The combination is used for balanced anesthesia, with propofol providing hypnosis and alfentanil providing analgesia and additional sedation.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Injection site pain
- Apnea
- Muscle rigidity
Key clinical trials
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Remimazolam for Bronchoscopy in High-Risk Patients (PHASE4)
- A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery (PHASE4)
- Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement (PHASE4)
- The Efficacy of Remimazolam on Incidence of Hypoxia During Sedated Transvaginal Oocyte Retrieval: A Multicenter Randomized Controlled Trial. (NA)
- Standardised Drug Provocation Testing in Perioperative Hypersensitivity (NA)
- Sedation of Remazolam Combined With Afentanil in Non-intubated Thoracoscopic Pulmonary Surgery (NA)
- Patient-Controlled Sedation in Port Implantation (PACSPI-2) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol + Alfentanil CI brief — competitive landscape report
- Propofol + Alfentanil updates RSS · CI watch RSS
- Region Jönköping County portfolio CI