Last reviewed · How we verify
Propofol Abbott
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system, leading to rapid onset of unconsciousness.
Propofol is a sedative-hypnotic agent that enhances inhibitory GABA neurotransmission in the central nervous system, leading to rapid onset of unconsciousness. Used for Induction and maintenance of general anesthesia, Sedation of intubated, mechanically ventilated patients in intensive care units.
At a glance
| Generic name | Propofol Abbott |
|---|---|
| Also known as | propofol |
| Sponsor | El-Sahel Teaching Hospital |
| Drug class | Sedative-hypnotic agent; GABA-A receptor positive allosteric modulator |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia; Critical Care |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing the frequency and duration of chloride channel opening. This hyperpolarizes neuronal membranes and suppresses neuronal firing, resulting in sedation, hypnosis, and anesthesia. It has rapid onset and offset kinetics due to its lipophilic nature and rapid redistribution from the central nervous system.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation of intubated, mechanically ventilated patients in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
- Propofol infusion syndrome (with prolonged high-dose infusion)
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Effect of Remimazolam and Propofol on Postoperative Delirium (NA)
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Actualities in Procedural Sedation: Remimazolam (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol Abbott CI brief — competitive landscape report
- Propofol Abbott updates RSS · CI watch RSS
- El-Sahel Teaching Hospital portfolio CI