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Propofol 1%
Propofol is a rapid-acting intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system, producing sedation and unconsciousness.
Propofol is a rapid-acting intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system, producing sedation and unconsciousness. Used for Induction and maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units, Sedation for diagnostic and therapeutic procedures.
At a glance
| Generic name | Propofol 1% |
|---|---|
| Also known as | Propofol-Lipuro 1%, propofol, ANESVAN INJECTION 10MG/ML (PROPOFOL) "CHI SHENG" |
| Sponsor | B. Braun Melsungen AG |
| Drug class | Intravenous anesthetic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and hyperpolarizing neuronal membranes. This enhancement of GABAergic inhibition leads to rapid onset of sedation and anesthesia. The drug is highly lipophilic, allowing rapid blood-brain barrier penetration and quick onset/offset of action.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in mechanically ventilated patients in intensive care units
- Sedation for diagnostic and therapeutic procedures
Common side effects
- Hypotension
- Apnea
- Bradycardia
- Injection site pain
- Hypertension
- Tachycardia
- Propofol infusion syndrome (with prolonged use)
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives (NA)
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Effect of Remimazolam and Propofol on Postoperative Delirium (NA)
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Actualities in Procedural Sedation: Remimazolam (PHASE4)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- THRIVE in Sedated Gastrointestinal Endoscopy
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol 1% CI brief — competitive landscape report
- Propofol 1% updates RSS · CI watch RSS
- B. Braun Melsungen AG portfolio CI