Last reviewed 2026-04-23 · How we verify

Progesterone Lozenges

Progesterone acts as a steroid hormone that binds to progesterone receptors to modulate reproductive and metabolic processes.

Progesterone acts as a steroid hormone that binds to progesterone receptors to modulate reproductive and metabolic processes. Used for Progesterone supplementation in pregnancy (likely indication given phase 3 status), Menstrual cycle regulation or hormone replacement therapy (potential indication).

At a glance

Mechanism of action

Progesterone is a naturally occurring steroid hormone that exerts its effects by binding to intracellular progesterone receptors (PR-A and PR-B), which function as ligand-activated transcription factors. The lozenge formulation allows for buccal/oral mucosal absorption, potentially providing more direct systemic delivery compared to other routes. This mechanism supports progesterone's role in maintaining pregnancy, regulating menstrual cycles, and modulating endometrial and breast tissue.

Approved indications

• Progesterone supplementation in pregnancy (likely indication given phase 3 status)
• Menstrual cycle regulation or hormone replacement therapy (potential indication)

Common side effects

• Headache
• Dizziness
• Nausea
• Breast tenderness
• Mood changes

Key clinical trials

• Smoking Cessation and Menstrual Cycle Phase (PHASE4)
• Progesterone vs Placebo Therapy for Women With Epilepsy (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Progesterone Lozenges CI brief — competitive landscape report
• Progesterone Lozenges updates RSS · CI watch RSS
• Beth Israel Deaconess Medical Center portfolio CI