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procaine penicillin, gentamicin, amoxicillin
Procaine penicillin is a combination antibiotic that works by inhibiting bacterial cell wall synthesis and protein synthesis, while gentamicin is an aminoglycoside antibiotic that works by inhibiting protein synthesis, and amoxicillin is a beta-lactam antibiotic that works by inhibiting cell wall synthesis.
Procaine penicillin is a combination antibiotic that works by inhibiting bacterial cell wall synthesis and protein synthesis, while gentamicin is an aminoglycoside antibiotic that works by inhibiting protein synthesis, and amoxicillin is a beta-lactam antibiotic that works by inhibiting cell wall synthesis. Used for Treatment of bacterial infections, including pneumonia, meningitis, and septicemia.
At a glance
| Generic name | procaine penicillin, gentamicin, amoxicillin |
|---|---|
| Sponsor | Aga Khan University |
| Drug class | Combination antibiotic |
| Target | Penicillin-binding proteins, 30S ribosomal subunit |
| Modality | Small molecule |
| Therapeutic area | Infectious diseases |
| Phase | Phase 3 |
Mechanism of action
Procaine penicillin, gentamicin, and amoxicillin are all bactericidal agents that target different aspects of bacterial physiology. Procaine penicillin and amoxicillin inhibit cell wall synthesis by binding to penicillin-binding proteins, while gentamicin inhibits protein synthesis by binding to the 30S ribosomal subunit. This combination of antibiotics is used to treat a variety of bacterial infections.
Approved indications
- Treatment of bacterial infections, including pneumonia, meningitis, and septicemia
Common side effects
- Nausea
- Vomiting
- Diarrhea
- Allergic reactions
- Neurotoxicity
Key clinical trials
- Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (PHASE3)
- Efficacy of LiveSpo Navax in Supportive Treatment of Pneumonia in Children With RSV and Bacterial Co-infections (NA)
- A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia (PHASE3)
- Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children (PHASE4)
- Antibiotic Profile of Pathogenic Bacteria Isolated in Public Hospitals in Northern Jordan
- RCT of Efficacy of Amoxicillin Over Ampicillin on Severe Pneumonia (NA)
- Patients Response to Early Switch To Oral:Osteomyelitis Study (EARLY_PHASE1)
- Innovative Treatments in Pneumonia (ITIP) 3
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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