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Prilocaine 2.5%
Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve blocks, and topical application, Dental anesthesia, Minor surgical procedures.
At a glance
| Generic name | Prilocaine 2.5% |
|---|---|
| Also known as | Prilocaine |
| Sponsor | Express Specialty Pharmacy |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Prilocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which stabilizes the neuronal membrane and raises the threshold for electrical excitability. This prevents depolarization and action potential propagation, resulting in local anesthesia in the area of administration. It is an amide-type local anesthetic with intermediate potency and duration.
Approved indications
- Local anesthesia for infiltration, nerve blocks, and topical application
- Dental anesthesia
- Minor surgical procedures
Common side effects
- Methemoglobinemia
- Allergic reactions
- Systemic toxicity (CNS and cardiac effects at high doses)
- Local irritation or pain at injection site
Key clinical trials
- Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars (NA)
- Virtual Reality Goggle Utilization for Venipuncture Distraction (NA)
- Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face (PHASE2, PHASE3)
- Oral Hyoscine vs. Topical EMLA vs. Placebo for Pain Reduction During Hysterosalpingography (NA)
- Efficacy Of Combined Microneedling Plus Tretinoin In Treatment Of Stria Rubra (PHASE1)
- Use of Cervical Cap and Menstrual Disc for Application of Topical Anesthetic Prior to IUD Insertion (NA)
- Local Anesthesia Before Bulkamid Injection (NA)
- Pharmacological and Nonpharmacological Methods for Children in Venipuncture Pain (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Prilocaine 2.5% CI brief — competitive landscape report
- Prilocaine 2.5% updates RSS · CI watch RSS
- Express Specialty Pharmacy portfolio CI