Last reviewed 2026-04-22 · How we verify

Preservative Free eye drop

Preservative-free eye drops provide lubrication and moisture to the ocular surface without chemical preservatives that may cause irritation.

Preservative-free eye drops provide lubrication and moisture to the ocular surface without chemical preservatives that may cause irritation. Used for Dry eye disease, Ocular surface irritation and lubrication.

At a glance

Mechanism of action

These drops deliver artificial tears or active pharmaceutical ingredients in a formulation free of antimicrobial preservatives, reducing the risk of preservative-induced ocular toxicity and irritation. They are typically dispensed in single-dose units or preservative-free multi-dose containers to maintain sterility without chemical additives. This formulation is particularly beneficial for patients with sensitive eyes or those requiring frequent instillation.

Approved indications

• Dry eye disease
• Ocular surface irritation and lubrication

Common side effects

• Mild ocular irritation
• Transient blurred vision
• Foreign body sensation

Key clinical trials

• SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease (PHASE4)
• A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease (PHASE3)
• The Development of New Functions of Esculin and Digitalis Glycosides Eye Drops: A Study on the Treatment of Presbyopia (PHASE4)
• AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension (PHASE1, PHASE2)
• A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes (PHASE3)
• Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction (PHASE4)
• Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST) (NA)
• Oxymetazoline Drops for Acquired Blepharoptosis From Synkinesis (PHASE3)

Primary sources

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