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Preoperative Oxycodone

Oxycodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation for preoperative pain management.

Oxycodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation for preoperative pain management. Used for Preoperative analgesia and anxiolysis in surgical patients.

At a glance

Mechanism of action

Oxycodone activates mu opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing analgesic and anxiolytic effects. When administered preoperatively, it reduces patient anxiety and provides baseline analgesia prior to surgery, potentially reducing intraoperative anesthetic requirements. The drug crosses the blood-brain barrier readily due to its lipophilic nature, making it effective for systemic pain relief.

Approved indications

• Preoperative analgesia and anxiolysis in surgical patients

Common side effects

• Respiratory depression
• Sedation
• Nausea and vomiting
• Dizziness
• Constipation
• Pruritus

Key clinical trials

• Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
• Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports (PHASE4)
• The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair (PHASE4)
• An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service (PHASE3)
• Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section (NA)
• Personalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB) (NA)
• NSAID Use After Robotic Partial Nephrectomy (PHASE2)
• ACU_Knee: Role of Acupuncture in Knee Prosthetic Surgery (NA)

Primary sources

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