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Pregnyl: Human chorionic gonadotrophin
Human chorionic gonadotrophin (hCG) mimics luteinizing hormone to stimulate testosterone production in males and ovulation in females.
Human chorionic gonadotrophin (hCG) mimics luteinizing hormone to stimulate testosterone production in males and ovulation in females. Used for Male hypogonadism and testosterone deficiency, Female infertility and ovulation induction, Cryptorchidism in prepubertal boys.
At a glance
| Generic name | Pregnyl: Human chorionic gonadotrophin |
|---|---|
| Also known as | Pregnyl |
| Sponsor | Genuine Research Center, Egypt |
| Drug class | Gonadotrophin |
| Target | Luteinizing hormone receptor (LH receptor) |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
Pregnyl is a recombinant or extracted form of hCG, a glycoprotein hormone that binds to luteinizing hormone receptors on Leydig cells (in males) and ovarian cells (in females). In males, it stimulates testosterone synthesis; in females, it triggers the LH surge necessary for ovulation. It is commonly used to support fertility and hormone replacement in hypogonadal conditions.
Approved indications
- Male hypogonadism and testosterone deficiency
- Female infertility and ovulation induction
- Cryptorchidism in prepubertal boys
Common side effects
- Injection site reactions (pain, swelling, bruising)
- Headache
- Mood changes
- Ovarian hyperstimulation syndrome (OHSS) in females
- Gynecomastia
Key clinical trials
- Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated Corticosteroids (PHASE1, PHASE2)
- INTEnsity of ovariaN Stimulation and Embryo Quality (PHASE4)
- Impact Of FET Preparation Protocol On Endometrial Peristalsis: A Prospective Cohort Study
- Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm (PHASE2)
- Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule (NA)
- Assessment of the Feasibility of Frozen Embryo Transfers in a Natural Cycle Among Obese Compared to Non-Obese Patients
- PTCY Plus uhCG/EGF for Graft Versus Host Disease Prophylaxis (PHASE1)
- FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cycles (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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