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Prazosin Hcl (prazosin-hcl)
Prazosin Hcl (generic name: prazosin-hcl) is a prazosin drug developed by Pfizer. It is currently FDA-approved (first approved 1976) for Hypertension, Lowering blood pressure, Reducing the risk of fatal and nonfatal cardiovascular events.
Prazosin Hcl is a small molecule that acts as an adrenergic receptor alpha-1 antagonist. It has been studied in clinical trials for various conditions, including Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD), Essential Hypertension, Cardiovascular Disease, and Stroke.
At a glance
| Generic name | prazosin-hcl |
|---|---|
| Sponsor | Pfizer |
| Drug class | prazosin |
| Target | 5-hydroxytryptamine receptor 1D |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
| First approval | 1976 |
Approved indications
- Hypertension
- Lowering blood pressure
- Reducing the risk of fatal and nonfatal cardiovascular events
- Reducing the risk of stroke
- Reducing the risk of myocardial infarctions
- Reducing cardiovascular mortality
Common side effects
- dizziness
- headache
- drowsiness
- lack of energy
- weakness
- palpitations
- nausea
- vomiting
- diarrhea
- constipation
- edema
- orthostatic hypotension
Drug interactions
- P-glycoprotein Substrates
- sildenafil
- tadalafil
Key clinical trials
- Alpha-1 Blockade for Alcohol Use Disorder (AUD) (PHASE2)
- A Study to Learn How Different Forms of the Study Medicine Called Prazosin Are Taken up Into the Blood in Healthy Adults (PHASE1)
- Brain Blood Vessel Responses to Changes in Blood Flow (PHASE2)
- Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests (PHASE3)
- Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort (PHASE2)
- Prazosin for Alcohol Use Disorder With Withdrawal Symptoms (PHASE2)
- Efficacy of Prazosin in Preventing Post-traumatic Stress Disorder (PHASE2)
- Doxazosin an a1 Antagonist for Alcohol Dependence (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Prazosin Hcl CI brief — competitive landscape report
- Prazosin Hcl updates RSS · CI watch RSS
- Pfizer portfolio CI
Frequently asked questions about Prazosin Hcl
What is Prazosin Hcl?
What is Prazosin Hcl used for?
Who makes Prazosin Hcl?
What is the generic name of Prazosin Hcl?
What drug class is Prazosin Hcl in?
When was Prazosin Hcl approved?
What development phase is Prazosin Hcl in?
What are the side effects of Prazosin Hcl?
What does Prazosin Hcl target?
Related
- Drug class: All prazosin drugs
- Target: All drugs targeting 5-hydroxytryptamine receptor 1D
- Manufacturer: Pfizer — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension
- Indication: Drugs for Lowering blood pressure
- Indication: Drugs for Reducing the risk of fatal and nonfatal cardiovascular events
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing