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Povidone-iodine irrigation
Povidone-iodine irrigation delivers iodine to tissues to disinfect and sterilize surgical or wound sites through broad-spectrum antimicrobial activity.
Povidone-iodine irrigation delivers iodine to tissues to disinfect and sterilize surgical or wound sites through broad-spectrum antimicrobial activity. Used for Surgical site irrigation and disinfection, Wound irrigation and cleansing, Preoperative skin antisepsis.
At a glance
| Generic name | Povidone-iodine irrigation |
|---|---|
| Also known as | Betadine |
| Sponsor | Corewell Health East |
| Drug class | Topical antiseptic/disinfectant |
| Modality | Small molecule |
| Therapeutic area | Infection prevention / Surgical care |
| Phase | FDA-approved |
Mechanism of action
Povidone-iodine is a complex of iodine and povidone (polyvinylpyrrolidone) that releases iodine when applied topically or via irrigation. The iodine penetrates microbial cell membranes and oxidizes essential proteins and nucleic acids, killing bacteria, viruses, fungi, and some protozoa. It is commonly used as a surgical scrub and irrigation solution to reduce infection risk in wounds and operative fields.
Approved indications
- Surgical site irrigation and disinfection
- Wound irrigation and cleansing
- Preoperative skin antisepsis
Common side effects
- Local irritation or burning
- Allergic contact dermatitis
- Iodine sensitivity reactions
- Systemic iodine absorption (rare with irrigation use)
Key clinical trials
- Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder (NA)
- CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee (NA)
- Povidone-Iodine Nasal Irrigation After Surgery for Chronic Rhinosinusitis (NA)
- Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty (PHASE1)
- Influence of Antiseptic Washes on Wound Healing Complications After THA (NA)
- Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
- Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (NA)
- APPI-Cost Trial for Perforated Appendicitis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |