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Postoperative epidural analgesia
Postoperative epidural analgesia delivers opioids and/or local anesthetics directly into the epidural space to block pain signals from surgical sites.
Postoperative epidural analgesia delivers opioids and/or local anesthetics directly into the epidural space to block pain signals from surgical sites. Used for Postoperative pain management following major surgery.
At a glance
| Generic name | Postoperative epidural analgesia |
|---|---|
| Also known as | Epidural analgesia with morphine and ropivacaine |
| Sponsor | University Hospital of Split |
| Drug class | Regional anesthetic/analgesic technique |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
This is a regional anesthesia technique that administers analgesic medications (commonly opioids like morphine or fentanyl, and/or local anesthetics like bupivacaine) into the epidural space surrounding the spinal cord. The medications diffuse across the dura to block nociceptive transmission and provide localized pain relief in the postoperative period, reducing systemic opioid requirements and associated side effects.
Approved indications
- Postoperative pain management following major surgery
Common side effects
- Hypotension
- Urinary retention
- Pruritus
- Nausea and vomiting
- Epidural hematoma
- Epidural abscess
- Lower limb motor block
Key clinical trials
- Genicular Nerve Block Added to Femoral Nerve Block for Analgesia After Total Knee Arthroplasty (NA)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy (PHASE4)
- Evaluating the Effectiveness of Postoperative Analgesic Methods in Thoracotomy Cases
- Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery. (NA)
- Ultrasound-Guided Transversus Abdominis Plane Block Versus Epidural Block for Umbilical Hernia Analgesia
- Postoperative Pain and Analgesic Use After Total Knee Arthroplasty
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Postoperative epidural analgesia CI brief — competitive landscape report
- Postoperative epidural analgesia updates RSS · CI watch RSS
- University Hospital of Split portfolio CI