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Polyethylene glycol (PEG)
Polyethylene glycol (PEG) is a Osmotic laxative Small molecule drug developed by Xian-Janssen Pharmaceutical Ltd.. It is currently FDA-approved for Constipation, Bowel preparation prior to colonoscopy or other gastrointestinal procedures. Also known as: Split-dose PEG Prep, High-dose Bowel Preparation Regimen, Klean-Prep, PEG.
Polyethylene glycol (PEG) is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements.
Polyethylene glycol (PEG) is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements. Used for Constipation, Bowel preparation prior to colonoscopy or other gastrointestinal procedures.
At a glance
| Generic name | Polyethylene glycol (PEG) |
|---|---|
| Also known as | Split-dose PEG Prep, High-dose Bowel Preparation Regimen, Klean-Prep, PEG, Colyte |
| Sponsor | Xian-Janssen Pharmaceutical Ltd. |
| Drug class | Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
PEG is a non-absorbable polymer that remains in the gastrointestinal tract and exerts an osmotic effect, increasing intraluminal fluid volume and stool bulk. This mechanical action stimulates peristalsis and facilitates evacuation of bowel contents. It is commonly used in bowel preparation solutions and as a standalone laxative for constipation management.
Approved indications
- Constipation
- Bowel preparation prior to colonoscopy or other gastrointestinal procedures
Common side effects
- Nausea
- Abdominal bloating or distension
- Abdominal cramping
- Vomiting
- Diarrhea
Key clinical trials
- A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia (PHASE3)
- A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis (PHASE3)
- A Study in Healthy Men to Find Out How BI 425809 is Taken up and Handled by the Body (PHASE1)
- The Efficacy and Palatability of Developed Polyethylene Glycol-based Formula for Children With Functional Constipation (NA)
- Biologic Treatment Withdrawal in Takayasu Arteritis Patients in Sustained Remission (NA)
- Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery (PHASE4)
- Varithena Versus Endothermal Ablation of the Great Saphenous Vein (VERITAS) (PHASE4)
- Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Polyethylene glycol (PEG) CI brief — competitive landscape report
- Polyethylene glycol (PEG) updates RSS · CI watch RSS
- Xian-Janssen Pharmaceutical Ltd. portfolio CI
Frequently asked questions about Polyethylene glycol (PEG)
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Related
- Drug class: All Osmotic laxative drugs
- Manufacturer: Xian-Janssen Pharmaceutical Ltd. — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Constipation
- Indication: Drugs for Bowel preparation prior to colonoscopy or other gastrointestinal procedures
- Also known as: Split-dose PEG Prep, High-dose Bowel Preparation Regimen, Klean-Prep, PEG, Colyte
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing