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polyethylene glycol +Bisacodyl
polyethylene glycol +Bisacodyl is a Combination laxative (osmotic + stimulant) Small molecule drug developed by Medical University of Warsaw. It is currently FDA-approved for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures, Constipation management. Also known as: Polyethylene glycol: Fortrans.
Polyethylene glycol acts as an osmotic laxative to draw water into the bowel, while bisacodyl stimulates colonic muscle contractions to promote bowel evacuation.
Polyethylene glycol acts as an osmotic laxative to draw water into the bowel, while bisacodyl stimulates colonic muscle contractions to promote bowel evacuation. Used for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures, Constipation management.
At a glance
| Generic name | polyethylene glycol +Bisacodyl |
|---|---|
| Also known as | Polyethylene glycol: Fortrans |
| Sponsor | Medical University of Warsaw |
| Drug class | Combination laxative (osmotic + stimulant) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Polyethylene glycol (PEG) is a non-absorbable osmotic agent that increases stool water content and volume, facilitating bowel movement. Bisacodyl is a stimulant laxative that directly irritates the colonic mucosa and increases peristalsis. Together, they provide both osmotic and mechanical promotion of defecation, commonly used for bowel cleansing prior to diagnostic or surgical procedures.
Approved indications
- Bowel cleansing prior to colonoscopy or other gastrointestinal procedures
- Constipation management
Common side effects
- Abdominal cramping
- Nausea
- Bloating
- Diarrhea
- Vomiting
Key clinical trials
- 4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy (NA)
- Examining the Effect of Ondansetron on Bowel Prep Success (PHASE4)
- What Laxative Should be Used After Hip Fracture Surgery? (PHASE4)
- Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults (NA)
- Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids (PHASE4)
- Retrospective, Uncontrolled Cohort Study on the Therapy of Chronic Megalon
- Testing How Well Magnesium Citrate Capsules Work as Preparation for a Colonoscopy (NA)
- Comparison of Two Types of Bowel Preparation for Inpatient Colonoscopy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- polyethylene glycol +Bisacodyl CI brief — competitive landscape report
- polyethylene glycol +Bisacodyl updates RSS · CI watch RSS
- Medical University of Warsaw portfolio CI
Frequently asked questions about polyethylene glycol +Bisacodyl
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Related
- Drug class: All Combination laxative (osmotic + stimulant) drugs
- Manufacturer: Medical University of Warsaw — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures
- Indication: Drugs for Constipation management
- Also known as: Polyethylene glycol: Fortrans
- Compare: polyethylene glycol +Bisacodyl vs similar drugs
- Pricing: polyethylene glycol +Bisacodyl cost, discount & access