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Polyethylene glycol and bisacodyl
Polyethylene glycol and bisacodyl is a Combination laxative (osmotic + stimulant) Small molecule drug developed by Taipei Medical University WanFang Hospital. It is currently FDA-approved for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures, Constipation management. Also known as: Dulcolax®, Klean-prep®.
Polyethylene glycol acts as an osmotic laxative to draw water into the bowel, while bisacodyl stimulates colonic muscle contractions to promote bowel evacuation.
Polyethylene glycol acts as an osmotic laxative to draw water into the bowel, while bisacodyl stimulates colonic muscle contractions to promote bowel evacuation. Used for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures, Constipation management.
At a glance
| Generic name | Polyethylene glycol and bisacodyl |
|---|---|
| Also known as | Dulcolax®, Klean-prep® |
| Sponsor | Taipei Medical University WanFang Hospital |
| Drug class | Combination laxative (osmotic + stimulant) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Polyethylene glycol (PEG) is a non-absorbable osmotic agent that increases stool water content by retaining fluid in the intestinal lumen, softening stool and promoting passage. Bisacodyl is a stimulant laxative that directly irritates the colonic mucosa and increases peristalsis, enhancing bowel motility. Together, these agents provide both osmotic and mechanical effects for bowel cleansing and evacuation.
Approved indications
- Bowel cleansing prior to colonoscopy or other gastrointestinal procedures
- Constipation management
Common side effects
- Abdominal discomfort or cramping
- Nausea
- Bloating
- Diarrhea
- Dehydration
Key clinical trials
- 4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy (NA)
- Examining the Effect of Ondansetron on Bowel Prep Success (PHASE4)
- What Laxative Should be Used After Hip Fracture Surgery? (PHASE4)
- Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults (NA)
- Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids (PHASE4)
- Retrospective, Uncontrolled Cohort Study on the Therapy of Chronic Megalon
- Comparison of Two Types of Bowel Preparation for Inpatient Colonoscopy (PHASE4)
- A Study of the Efficacy and Safety of Bowklean and Klean-Prep With Dulcolax for the Bowel Preparation Prior Colonoscopy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Polyethylene glycol and bisacodyl CI brief — competitive landscape report
- Polyethylene glycol and bisacodyl updates RSS · CI watch RSS
- Taipei Medical University WanFang Hospital portfolio CI
Frequently asked questions about Polyethylene glycol and bisacodyl
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Related
- Drug class: All Combination laxative (osmotic + stimulant) drugs
- Manufacturer: Taipei Medical University WanFang Hospital — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures
- Indication: Drugs for Constipation management
- Also known as: Dulcolax®, Klean-prep®
- Compare: Polyethylene glycol and bisacodyl vs similar drugs
- Pricing: Polyethylene glycol and bisacodyl cost, discount & access