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Polyethylene Glycol 4000 with electrolytes
Polyethylene glycol 4000 with electrolytes acts as an osmotic laxative that draws water into the bowel lumen while the electrolytes maintain fluid and electrolyte balance.
Polyethylene glycol 4000 with electrolytes acts as an osmotic laxative that draws water into the bowel lumen while the electrolytes maintain fluid and electrolyte balance. Used for Constipation, Bowel preparation prior to colonoscopy or other gastrointestinal procedures.
At a glance
| Generic name | Polyethylene Glycol 4000 with electrolytes |
|---|---|
| Also known as | Bohm solution®, Colonsoft |
| Sponsor | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla |
| Drug class | Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
PEG 4000 is a non-absorbable polymer that creates an osmotic gradient in the intestinal lumen, pulling water into the bowel and increasing stool bulk and motility. The added electrolytes (typically sodium chloride, potassium chloride, sodium bicarbonate, and sodium sulfate) prevent net fluid and electrolyte shifts, making it a balanced bowel preparation solution suitable for both therapeutic use and colonoscopy preparation.
Approved indications
- Constipation
- Bowel preparation prior to colonoscopy or other gastrointestinal procedures
Common side effects
- Nausea
- Abdominal bloating or distension
- Abdominal cramping
- Vomiting
- Diarrhea
Key clinical trials
- Clinical Study of PEG Bowel Preparation in Appendectomy Patients
- The Associations Between Gut Length, Gut Microbiota and Food Assimilation
- Pre-packaged Low-residue Diet for Bowel Preparation in Patients With Inflammatory Bowel Disease (NA)
- Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients (NA)
- What Laxative Should be Used After Hip Fracture Surgery? (PHASE4)
- Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen (PHASE4)
- Clinical Study of Bowel Preparation Before Colonoscopy (NA)
- Study on the Safety and Efficacy of Sodium Phosphate Powder for Intestinal Preparation in People Aged 50 to 70 Years Old (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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