Last reviewed 2026-04-23 · How we verify

Polio Sabin

The Polio Sabin vaccine works by introducing a weakened form of the poliovirus to stimulate an immune response.

The Polio Sabin vaccine works by introducing a weakened form of the poliovirus to stimulate an immune response. Used for Polio prevention.

At a glance

Mechanism of action

This immune response helps the body recognize and fight the poliovirus, providing protection against polio infection. The vaccine is administered orally and contains three different strains of the weakened poliovirus.

Approved indications

• Polio prevention

Common side effects

• Gastrointestinal symptoms
• Fever

Key clinical trials

• Phase IV Clinical Study of sIPV Administration in Adolescent and Adult Populations (PHASE4)
• Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh (PHASE2)
• A Multi-center, Open-labelled, Randomized, Controlled, Extended Phase Ⅲ Clinical Trial of sIPV Vaccine (PHASE3)
• A Study on the Immune Response and Safety of Inactivated Poliovirus Vaccine (IPV) When Co-administered With Human Rotavirus (HRV) Porcine Circovirus (PCV)-Free Vaccine in Healthy Chinese Infants (PHASE3)
• Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines (PHASE1, PHASE2)
• Study of Concomitant Administration of the sIPV and DTaP or MMR (PHASE4)
• Study to Evaluate Eupolio(IPV)'s Safety, Long-term Protective Effect and Boosting Effect of One Booster Dose in the Three Primary Vaccination Plus Boosting Schedule, and Protective Effect in the Schedule With Bivalent OPV in Infants (PHASE3)
• Sequential Vaccination of Poliomyelitis Vaccine (Vero Cells), Inactivated, Sabin Strains From Different Manufacturers (PHASE4)

Primary sources

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