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Polihexanide 2%
Polihexanide is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes through electrostatic interactions.
Polihexanide is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes through electrostatic interactions. Used for Wound irrigation and antisepsis, Burn wound management, Chronic wound care.
At a glance
| Generic name | Polihexanide 2% |
|---|---|
| Sponsor | University of Sao Paulo |
| Drug class | Antiseptic/Antimicrobial agent |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Wound Care |
| Phase | Phase 3 |
Mechanism of action
Polihexanide is a biguanide-based antiseptic that works by binding to negatively charged microbial cell membranes, causing disruption and leakage of cellular contents. It exhibits rapid bactericidal and fungicidal activity against a wide range of gram-positive and gram-negative bacteria, as well as fungi and some viruses. The 2% formulation is typically used for wound irrigation and antiseptic applications.
Approved indications
- Wound irrigation and antisepsis
- Burn wound management
- Chronic wound care
Common side effects
- Local irritation or burning sensation
- Allergic contact dermatitis
- Tissue toxicity at high concentrations
Key clinical trials
- Efficacy of a Polyhexanide Biguanide-Based Gel in the Prevention of Biofilm Formation in Pressure Ulcers (EARLY_PHASE1)
- Parasitic Ulcer Treatment Trial (PHASE3)
- UROtainer for Bladder Catheter Maintenance, Infection Prevention and Quality of Life (NA)
- Acetic Acid 2% Solution for Skin Ulcers (PHASE3)
- Ostomy Primary Closure With 0.1% Betaine/Polyhexanide Wound Irrigation Compared to Pursestring Closure (PHASE4)
- A Study to Evaluate the Efficacy of a Purified Native Type 1 Collagen Extracellular Matrix With Polyhexamethylene Biguanide Antimicrobial (PCMP) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers (NA)
- Effect of Two Different Solutions on Wound Healing in Pressure Injury (NA)
- Treating Diabetic Foot Ulcers, Comparing Two Topical Antimicrobial Agents, Dakin´s and Prontosan (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Polihexanide 2% CI brief — competitive landscape report
- Polihexanide 2% updates RSS · CI watch RSS
- University of Sao Paulo portfolio CI