Last reviewed · How we verify
Placebo (one of medication)
Placebo produces therapeutic effects through patient expectation and the psychobiological placebo response, rather than through a pharmacologically active ingredient.
Placebo produces therapeutic effects through patient expectation and the psychobiological placebo response, rather than through a pharmacologically active ingredient. Used for Used as control comparator in clinical trials across multiple therapeutic areas.
At a glance
| Generic name | Placebo (one of medication) |
|---|---|
| Also known as | patient in group C will receive none of medication |
| Sponsor | Chung-Ang University Hosptial, Chung-Ang University College of Medicine |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
Placebo works by activating the patient's expectation of benefit, which can trigger real neurobiological changes including endogenous opioid release, dopamine activation, and modulation of pain perception and symptom severity. This effect is particularly pronounced in conditions with subjective symptom components such as pain, nausea, fatigue, and anxiety, though it can also produce measurable physiological changes in some objective parameters.
Approved indications
- Used as control comparator in clinical trials across multiple therapeutic areas
Common side effects
- Nocebo effects (adverse events attributed to placebo expectation)
Key clinical trials
- Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE. (PHASE2)
- Adenosine 2A Receptor Antagonism and AIH in ALS (PHASE1, PHASE2)
- Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN) (PHASE2)
- A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE) (PHASE3)
- A Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive Medicine (PHASE2)
- Efficacy of Cabergoline in Inhibiting Lactation and Alleviating Breast Symptoms (PHASE2)
- Traditional Chinese Medicine Preparation Alleviates Radiotherapy-induced Oral Mucositis in Head and Neck Cancer Patients. (PHASE2)
- FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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