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Placebo + Letrozole/Anastrozole
Placebo + Letrozole/Anastrozole is a Aromatase inhibitor Small molecule drug developed by Xuanzhu Biopharmaceutical Co., Ltd.. It is currently in Phase 3 development for Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women, Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women.
Letrozole and Anastrozole are aromatase inhibitors that block the enzyme responsible for converting androgens to estrogens, thereby reducing estrogen levels in the body.
Letrozole and Anastrozole are aromatase inhibitors that block the enzyme responsible for converting androgens to estrogens, thereby reducing estrogen levels in the body. Used for Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women, Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women.
At a glance
| Generic name | Placebo + Letrozole/Anastrozole |
|---|---|
| Sponsor | Xuanzhu Biopharmaceutical Co., Ltd. |
| Drug class | Aromatase inhibitor |
| Target | Aromatase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
By inhibiting the aromatase enzyme, these drugs decrease the production of estrogen, which can slow the growth of hormone receptor-positive breast cancer cells. This mechanism is particularly effective in postmenopausal women, as their bodies produce less estrogen naturally.
Approved indications
- Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women
- Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women
Common side effects
- Hot flashes
- Vaginal dryness
- Musculoskeletal pain
- Fatigue
- Headache
Key clinical trials
- A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA) (PHASE3)
- A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer (PHASE3)
- S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer (PHASE3)
- A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer (PHASE3)
- A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer (PHASE3)
- Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6) (PHASE3)
- Efficacy and Safety of Ribociclib in Pre- and Postmenopausal Chinese Women With HR Positive, HER2-negative, Advanced Breast Cancer. (PHASE2)
- A Study of XZP-3287 in Combination With Letrozole/Anastrozole in Patients With Advanced Breast Cancer (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo + Letrozole/Anastrozole CI brief — competitive landscape report
- Placebo + Letrozole/Anastrozole updates RSS · CI watch RSS
- Xuanzhu Biopharmaceutical Co., Ltd. portfolio CI
Frequently asked questions about Placebo + Letrozole/Anastrozole
What is Placebo + Letrozole/Anastrozole?
How does Placebo + Letrozole/Anastrozole work?
What is Placebo + Letrozole/Anastrozole used for?
Who makes Placebo + Letrozole/Anastrozole?
What drug class is Placebo + Letrozole/Anastrozole in?
What development phase is Placebo + Letrozole/Anastrozole in?
What are the side effects of Placebo + Letrozole/Anastrozole?
What does Placebo + Letrozole/Anastrozole target?
Related
- Drug class: All Aromatase inhibitor drugs
- Target: All drugs targeting Aromatase
- Manufacturer: Xuanzhu Biopharmaceutical Co., Ltd. — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women
- Indication: Drugs for Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women
- Compare: Placebo + Letrozole/Anastrozole vs similar drugs
- Pricing: Placebo + Letrozole/Anastrozole cost, discount & access