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Placebo in combination with nivolumab
Placebo in combination with nivolumab is a PD-1 inhibitor Small molecule drug developed by HUYABIO International, LLC.. It is currently in Phase 3 development for Metastatic non-small cell lung cancer, PD-L1 positive, Metastatic renal cell carcinoma, Adenocarcinoma of the bladder. Also known as: For nivolumab: OPDIVO®.
Nivolumab is a PD-1 inhibitor that works by blocking the PD-1 receptor on T cells, allowing them to attack cancer cells.
Nivolumab is a PD-1 inhibitor that works by blocking the PD-1 receptor on T cells, allowing them to attack cancer cells. Used for Metastatic non-small cell lung cancer, PD-L1 positive, Metastatic renal cell carcinoma, Adenocarcinoma of the bladder.
At a glance
| Generic name | Placebo in combination with nivolumab |
|---|---|
| Also known as | For nivolumab: OPDIVO® |
| Sponsor | HUYABIO International, LLC. |
| Drug class | PD-1 inhibitor |
| Target | PD-1 |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
By blocking the PD-1 receptor, nivolumab allows T cells to recognize and attack cancer cells, leading to an immune response against the tumor. This mechanism is particularly effective in treating cancers with high PD-L1 expression.
Approved indications
- Metastatic non-small cell lung cancer, PD-L1 positive
- Metastatic renal cell carcinoma
- Adenocarcinoma of the bladder
- Adenocarcinoma of the esophagus
- Adenocarcinoma of the gastroesophageal junction
- Adenocarcinoma of the head and neck
- Adenocarcinoma of the liver
- Adenocarcinoma of the lung
- Adenocarcinoma of the pancreas
- Adenocarcinoma of the stomach
Common side effects
- Fatigue
- Diarrhea
- Nausea
- Rash
- Pruritus
- Hypothyroidism
- Hyperthyroidism
- Thyroiditis
- Pneumonitis
- Colitis
Key clinical trials
- Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial) (NA)
- SSRI Antidepressant Fluoxetine Improving Immunotherapy Efficacy in Advanced Hepatobiliary Malignancy Patients With Depression and Anxiety (PHASE2)
- A Study to Investigate the Efficacy and Safety of ONO-4578 in Combination With Nivolumab and Chemotherapy in Chemotherapy-naïve Participants With HER2-negative Unresectable Advanced or Recurrent Gastric Cancer (Including Esophagogastric Junction Cancer) (PHASE2)
- A Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers (PHASE1, PHASE2)
- Surgical Nivolumab And Ipilimumab For Recurrent GBM (PHASE1)
- A Study of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Participants With Advanced Kidney Cancer (PHASE3)
- A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer (PHASE1, PHASE2)
- PD-1 Antibody Therapy + Infliximab for Metastatic Melanoma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo in combination with nivolumab CI brief — competitive landscape report
- Placebo in combination with nivolumab updates RSS · CI watch RSS
- HUYABIO International, LLC. portfolio CI
Frequently asked questions about Placebo in combination with nivolumab
What is Placebo in combination with nivolumab?
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Is Placebo in combination with nivolumab also known as anything else?
What drug class is Placebo in combination with nivolumab in?
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Related
- Drug class: All PD-1 inhibitor drugs
- Target: All drugs targeting PD-1
- Manufacturer: HUYABIO International, LLC. — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic non-small cell lung cancer, PD-L1 positive
- Indication: Drugs for Metastatic renal cell carcinoma
- Indication: Drugs for Adenocarcinoma of the bladder
- Also known as: For nivolumab: OPDIVO®
- Compare: Placebo in combination with nivolumab vs similar drugs
- Pricing: Placebo in combination with nivolumab cost, discount & access