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Placebo (D5W)
Placebo (D5W) is a Small molecule drug developed by The Medicines Company. It is currently FDA-approved for Used as a placebo control in clinical trials. Also known as: 5% dextrose in water, Placebo, Vehicle, D5W.
D5W (dextrose 5% in water) is an intravenous fluid that provides hydration and a modest amount of glucose for energy.
D5W (dextrose 5% in water) is an intravenous fluid that provides hydration and a modest amount of glucose for energy. Used for Used as a placebo control in clinical trials.
At a glance
| Generic name | Placebo (D5W) |
|---|---|
| Also known as | 5% dextrose in water, Placebo, Vehicle, D5W |
| Sponsor | The Medicines Company |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
D5W is a crystalloid solution containing 5% dextrose dissolved in sterile water. It is administered intravenously to maintain fluid balance, provide basic caloric support, and deliver medications. As a placebo in clinical trials, it serves as an inactive comparator with no active pharmacological mechanism.
Approved indications
- Used as a placebo control in clinical trials
Common side effects
- Hyperglycemia
- Hyponatremia (with prolonged use)
- Phlebitis at infusion site
Key clinical trials
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (PHASE4)
- Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease (EARLY_PHASE1)
- Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke (PHASE2)
- Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo (PHASE4)
- Ceftriaxone for Post-Treatment Lyme Disease (PHASE1, PHASE2)
- Early Norepinephrine Administration and Rapid Dose Adjustment (NA)
- Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy (PHASE3)
- Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo (D5W) CI brief — competitive landscape report
- Placebo (D5W) updates RSS · CI watch RSS
- The Medicines Company portfolio CI
Frequently asked questions about Placebo (D5W)
What is Placebo (D5W)?
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Is Placebo (D5W) also known as anything else?
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Related
- Manufacturer: The Medicines Company — full pipeline
- Indication: Drugs for Used as a placebo control in clinical trials
- Also known as: 5% dextrose in water, Placebo, Vehicle, D5W
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing