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Placebo cream without active substance
A placebo cream contains no active pharmaceutical ingredient and produces therapeutic effects solely through the placebo effect.
A placebo cream contains no active pharmaceutical ingredient and produces therapeutic effects solely through the placebo effect. Used for Control comparator in phase 3 clinical trials (indication-dependent on active comparator).
At a glance
| Generic name | Placebo cream without active substance |
|---|---|
| Sponsor | Medinova AG |
| Modality | Small molecule |
| Phase | Phase 3 |
Mechanism of action
Placebo formulations are inert vehicles used as control comparators in clinical trials to establish the efficacy of active drugs above baseline and psychological expectation. In phase 3 trials, placebo creams help distinguish genuine pharmacological activity from subjective symptom improvement driven by patient expectation, therapeutic ritual, and natural disease course. Any observed benefit in placebo-treated groups reflects non-specific mechanisms including patient-reported outcomes bias and regression to the mean.
Approved indications
- Control comparator in phase 3 clinical trials (indication-dependent on active comparator)
Common side effects
- Skin irritation or sensitization (vehicle-related)
- Local erythema or pruritus
Key clinical trials
- Examine Impact of Topical Application of Active Versus Placebo on the Skin Microbiome in Sensitive Skin. (NA)
- A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome (PHASE1, PHASE2)
- Clinical Therapeutic Potential of Novel Microbiome LP-51 on Xerosis Individual Based on Xerosis-microbiome Index (PHASE1, PHASE2)
- Effectivity and Safety of Metronidazole 1% Cream in Rosacea Therapy (PHASE1)
- CyPep-1 in Cutaneous Warts (PHASE1)
- Efficacy and Tolerability of Hirudoid Cream in Prophylaxis and Treatment Infusion Phlebitis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo cream without active substance CI brief — competitive landscape report
- Placebo cream without active substance updates RSS · CI watch RSS
- Medinova AG portfolio CI