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Placebo capsules, Letrozole, Anastrozole, Tamoxifen
Placebo capsules, Letrozole, Anastrozole, Tamoxifen is a Aromatase inhibitor, SERM Small molecule drug developed by Chia Tai Tianqing Pharmaceutical Group Co., Ltd.. It is currently in Phase 3 development for Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women, Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women.
Letrozole and Anastrozole are aromatase inhibitors, which block the production of estrogen in the body. Tamoxifen is a selective estrogen receptor modulator (SERM), which blocks estrogen receptors in breast tissue.
Letrozole and Anastrozole are aromatase inhibitors, which block the production of estrogen in the body. Tamoxifen is a selective estrogen receptor modulator (SERM), which blocks estrogen receptors in breast tissue. Used for Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women, Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women.
At a glance
| Generic name | Placebo capsules, Letrozole, Anastrozole, Tamoxifen |
|---|---|
| Sponsor | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
| Drug class | Aromatase inhibitor, SERM |
| Target | Aromatase, Estrogen receptor |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Aromatase inhibitors like Letrozole and Anastrozole work by inhibiting the enzyme aromatase, which is responsible for converting androgens into estrogens. By blocking this enzyme, they reduce estrogen levels in the body. Tamoxifen, on the other hand, binds to estrogen receptors in breast tissue, blocking the action of estrogen and thereby inhibiting the growth of estrogen receptor-positive breast cancer cells.
Approved indications
- Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women
- Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women
Common side effects
- Hot flashes
- Vaginal dryness
- Musculoskeletal pain
- Fatigue
- Headache
Key clinical trials
- Study of Efficacy and Safety in Premenopausal Women With Hormone Receptor Positive, HER2-negative Advanced Breast Cancer (PHASE3)
- Clinical Study on Adjuvant Therapy of TQB3616 Combined With Endocrine Therapy Compared With Placebo Combined With Endocrine Therapy in Patients With Breast Cancer (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo capsules, Letrozole, Anastrozole, Tamoxifen CI brief — competitive landscape report
- Placebo capsules, Letrozole, Anastrozole, Tamoxifen updates RSS · CI watch RSS
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd. portfolio CI
Frequently asked questions about Placebo capsules, Letrozole, Anastrozole, Tamoxifen
What is Placebo capsules, Letrozole, Anastrozole, Tamoxifen?
How does Placebo capsules, Letrozole, Anastrozole, Tamoxifen work?
What is Placebo capsules, Letrozole, Anastrozole, Tamoxifen used for?
Who makes Placebo capsules, Letrozole, Anastrozole, Tamoxifen?
What drug class is Placebo capsules, Letrozole, Anastrozole, Tamoxifen in?
What development phase is Placebo capsules, Letrozole, Anastrozole, Tamoxifen in?
What are the side effects of Placebo capsules, Letrozole, Anastrozole, Tamoxifen?
What does Placebo capsules, Letrozole, Anastrozole, Tamoxifen target?
Related
- Drug class: All Aromatase inhibitor, SERM drugs
- Target: All drugs targeting Aromatase, Estrogen receptor
- Manufacturer: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women
- Indication: Drugs for Adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women
- Compare: Placebo capsules, Letrozole, Anastrozole, Tamoxifen vs similar drugs
- Pricing: Placebo capsules, Letrozole, Anastrozole, Tamoxifen cost, discount & access