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Placebo + Calcium and Vitamin D
Calcium and vitamin D supplementation supports bone mineralization and calcium homeostasis, while placebo serves as a control comparator in clinical trials.
Calcium and vitamin D supplementation supports bone mineralization and calcium homeostasis, while placebo serves as a control comparator in clinical trials. Used for Osteoporosis prevention and treatment, Bone health maintenance in aging populations.
At a glance
| Generic name | Placebo + Calcium and Vitamin D |
|---|---|
| Also known as | Placebo |
| Sponsor | Boston VA Research Institute, Inc. |
| Drug class | Nutritional supplement / Mineral and vitamin combination |
| Modality | Small molecule |
| Therapeutic area | Bone health / Osteoporosis prevention |
| Phase | FDA-approved |
Mechanism of action
Calcium is essential for bone formation and maintenance, while vitamin D enhances intestinal calcium absorption and regulates serum calcium levels. In this formulation, placebo is included as a control arm, likely in a randomized trial design to assess the efficacy of calcium and vitamin D supplementation against no active treatment.
Approved indications
- Osteoporosis prevention and treatment
- Bone health maintenance in aging populations
Common side effects
- Hypercalcemia
- Gastrointestinal upset
- Kidney stone formation
- Constipation
Key clinical trials
- Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity (PHASE2)
- Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia (PHASE2)
- Effects of Vitamin D and Calcium on Hyperglycemia and Dyslipidemia in Patients Gestational Diabetes (NA)
- Resveratrol for the Prevention of Bone Loss in Postmenopausal Women (NA)
- Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes (PHASE2)
- Setrusumab vs Placebo for Osteogenesis Imperfecta (PHASE2, PHASE3)
- This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When Administered Either Individually or in Combination Contributes to an Increased Quality of Health, Specifically Improving Muscular Strength and Cognitive Functioning in Adults Over the Age of 65. (NA)
- Romosozumab Use to Build Skeletal Integrity (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo + Calcium and Vitamin D CI brief — competitive landscape report
- Placebo + Calcium and Vitamin D updates RSS · CI watch RSS
- Boston VA Research Institute, Inc. portfolio CI