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Placebo - ascorbic acid
Ascorbic acid (vitamin C) acts as an antioxidant and cofactor for enzymatic reactions, reducing oxidative stress and supporting collagen synthesis and immune function.
Ascorbic acid (vitamin C) acts as an antioxidant and cofactor for enzymatic reactions, reducing oxidative stress and supporting collagen synthesis and immune function. Used for Placebo control in phase 3 clinical trial (specific indication unknown).
At a glance
| Generic name | Placebo - ascorbic acid |
|---|---|
| Sponsor | St. Joseph's Hospital and Medical Center, Phoenix |
| Drug class | Vitamin / Antioxidant |
| Modality | Small molecule |
| Phase | Phase 3 |
Mechanism of action
Ascorbic acid is a water-soluble vitamin that functions as a reducing agent and electron donor in various metabolic pathways. It serves as a cofactor for prolyl and lysyl hydroxylase enzymes essential for collagen cross-linking, and supports immune cell function through antioxidant mechanisms that neutralize reactive oxygen species. In the context of this phase 3 trial, ascorbic acid is being used as a placebo control, suggesting the active investigational agent's mechanism is being compared against vitamin C supplementation.
Approved indications
- Placebo control in phase 3 clinical trial (specific indication unknown)
Common side effects
- Gastrointestinal upset (nausea, diarrhea)
- Kidney stone formation (at high doses)
- Headache
Key clinical trials
- Toddler Biomarker of Nutrition Study (NA)
- The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists (PHASE1)
- Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation. (NA)
- Vitamin c Supplementation in the Prevention of CRPS Following Distal Radius Fractures (PHASE4)
- Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia (PHASE2)
- Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation? (NA)
- Combination Gerotherapeutic Interventions for Healthspan Improvement (PHASE3)
- Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1 (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |