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Piperacillin-tazobactam
Piperacillin-tazobactam is a Beta-lactam antibiotic with beta-lactamase inhibitor Small molecule drug developed by University Hospital, Bordeaux. It is currently FDA-approved for Bacterial infections including pneumonia, intra-abdominal infections, and urinary tract infections, Febrile neutropenia in cancer patients, Polymicrobial infections caused by beta-lactamase-producing organisms. Also known as: Piperacillin 4 g-Tazobactam 0.5 g, piperacillin-tazobactam combination product, PIPER/TAZO, Piperacillin/Tazobactam.
Piperacillin-tazobactam is a beta-lactam antibiotic combined with a beta-lactamase inhibitor that kills bacteria by inhibiting cell wall synthesis while protecting the antibiotic from enzymatic degradation.
Piperacillin-tazobactam is a combination medication that contains the antibiotic piperacillin and the β-lactamase inhibitor tazobactam, which has activity against many Gram-negative bacteria including Pseudomonas aeruginosa. It is used to treat conditions such as Gram-negative Bacteremia, Osteomyelitis, Bone and Joint Infection, Appendicitis, and Perforated Appendicitis, typically administered as an intravenous or oral antibiotic.
At a glance
| Generic name | Piperacillin-tazobactam |
|---|---|
| Also known as | Piperacillin 4 g-Tazobactam 0.5 g, piperacillin-tazobactam combination product, PIPER/TAZO, Piperacillin/Tazobactam, Zosyn |
| Sponsor | University Hospital, Bordeaux |
| Drug class | Beta-lactam antibiotic with beta-lactamase inhibitor |
| Target | Penicillin-binding proteins (PBPs); beta-lactamases |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Piperacillin is an extended-spectrum penicillin that binds to penicillin-binding proteins and disrupts bacterial cell wall cross-linking, leading to cell lysis and death. Tazobactam is a beta-lactamase inhibitor that irreversibly binds to and inactivates beta-lactamases produced by resistant bacteria, preventing degradation of piperacillin and restoring its activity against beta-lactamase-producing organisms.
Approved indications
- Bacterial infections including pneumonia, intra-abdominal infections, and urinary tract infections
- Febrile neutropenia in cancer patients
- Polymicrobial infections caused by beta-lactamase-producing organisms
Common side effects
- Diarrhea
- Nausea
- Rash
- Vomiting
- Headache
- Clostridium difficile-associated diarrhea
- Allergic reactions
Key clinical trials
- Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia (PHASE4)
- A Randomised Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients. (PHASE4)
- Subcutaneous Piperacillin/Tazobactam Compared With Intravenous Treatment (PHASE2)
- SYN-004 Safety and Tolerability in Allo-HCT Subjects (PHASE1, PHASE2)
- Evaluation of the Achievement of a Pharmacodynamic Target of Piperacillin-Tazobactam for the Population With Obesity (PHASE4)
- Aminoglycosides in Early Sepsis (PHASE4)
- Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial (NA)
- Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Piperacillin-tazobactam CI brief — competitive landscape report
- Piperacillin-tazobactam updates RSS · CI watch RSS
- University Hospital, Bordeaux portfolio CI
Frequently asked questions about Piperacillin-tazobactam
What is Piperacillin-tazobactam?
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Who makes Piperacillin-tazobactam?
Is Piperacillin-tazobactam also known as anything else?
What drug class is Piperacillin-tazobactam in?
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What does Piperacillin-tazobactam target?
Related
- Drug class: All Beta-lactam antibiotic with beta-lactamase inhibitor drugs
- Target: All drugs targeting Penicillin-binding proteins (PBPs); beta-lactamases
- Manufacturer: University Hospital, Bordeaux — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Bacterial infections including pneumonia, intra-abdominal infections, and urinary tract infections
- Indication: Drugs for Febrile neutropenia in cancer patients
- Indication: Drugs for Polymicrobial infections caused by beta-lactamase-producing organisms
- Also known as: Piperacillin 4 g-Tazobactam 0.5 g, piperacillin-tazobactam combination product, PIPER/TAZO, Piperacillin/Tazobactam, Zosyn
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing