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Pioglitazone + Alogliptin
Pioglitazone improves insulin sensitivity by activating PPAR-γ, while alogliptin inhibits DPP-4 to increase incretin levels, together reducing blood glucose in type 2 diabetes.
Pioglitazone improves insulin sensitivity by activating PPAR-γ, while alogliptin inhibits DPP-4 to increase incretin levels, together reducing blood glucose in type 2 diabetes. Used for Type 2 diabetes mellitus.
At a glance
| Generic name | Pioglitazone + Alogliptin |
|---|---|
| Also known as | SYR-322-4833 |
| Sponsor | Celltrion Pharm, Inc. |
| Drug class | Thiazolidinedione + DPP-4 inhibitor combination |
| Target | PPAR-γ and DPP-4 |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | FDA-approved |
Mechanism of action
Pioglitazone is a thiazolidinedione that acts as a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, enhancing insulin sensitivity in muscle and adipose tissue. Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), thereby increasing insulin secretion in response to meals. Together, they provide complementary glucose-lowering effects through improved peripheral insulin action and enhanced endogenous insulin secretion.
Approved indications
- Type 2 diabetes mellitus
Common side effects
- Hypoglycemia
- Weight gain
- Fluid retention / edema
- Headache
- Upper respiratory tract infection
Key clinical trials
- The Effect of Alogliptin Combined With Actoplus Met on Glucose and Lipid Metabolism and Pancreatic Function in Patients With T2DM Complicated With MAFLD (PHASE4)
- A Study to Evaluate the Effect of add-on Pioglitazone or Dapagliflozin in Participants With Type 2 Diabetes Mellitus Inadequately Controlled by DPP-4 Inhibitor and Metformin Therapy (PHASE4)
- Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study
- A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease
- Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh (PHASE4)
- Alogliptin/Pioglitazone (Liovel) Combination Tablets Survey on Long-term Use in Patients With Type 2 Diabetes Mellitus
- A Double-blind, Parallel Group, Comparative Study of Coadministration AD-4833 and SYR-322 (PHASE4)
- A Post-Marketing Surveillance Study on NesinaAct® Tablet Use Among Type 2 Diabetes Mellitus Participants in Korea
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pioglitazone + Alogliptin CI brief — competitive landscape report
- Pioglitazone + Alogliptin updates RSS · CI watch RSS
- Celltrion Pharm, Inc. portfolio CI