Last reviewed 2026-04-22 · How we verify

Physioneal 40

Physioneal 40 is a peritoneal dialysis fluid that facilitates ultrafiltration and solute removal in patients with renal failure by creating an osmotic gradient across the peritoneal membrane.

Physioneal 40 is a peritoneal dialysis fluid that facilitates ultrafiltration and solute removal across the peritoneal membrane during peritoneal dialysis treatment. Used for End-stage renal disease requiring peritoneal dialysis.

At a glance

Mechanism of action

Physioneal 40 is a balanced peritoneal dialysis solution containing 40 mmol/L of bicarbonate buffer and lactate, designed to reduce peritoneal inflammation and improve biocompatibility compared to conventional dialysates. The solution uses glucose as the osmotic agent to drive fluid removal while the buffering system helps maintain peritoneal pH and reduce glucose degradation products that can accumulate during dwell time.

Approved indications

• End-stage renal disease requiring peritoneal dialysis

Common side effects

• Peritonitis
• Abdominal pain
• Hyperglycemia
• Electrolyte imbalances

Key clinical trials

• Efficacy and Safety of XyloCore Peritoneal Dialysis Solution. (PHASE3)
• IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients (PHASE4)
• IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients (PHASE3)
• Randomized Multicenter Cross-over Study to Compare the Effect of Physioneal 35 to 40 on the Protein Metabolism (PHASE4)

Primary sources

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