Last reviewed 2026-04-22 · How we verify

Physioneal 35

Physioneal 35 is a peritoneal dialysis fluid formulated to optimize electrolyte balance and reduce peritoneal membrane injury during dialysate exchange.

Physioneal 35 is a peritoneal dialysis fluid formulated to optimize electrolyte balance and reduce peritoneal membrane injury during dialysate exchange. Used for Peritoneal dialysis in end-stage renal disease (ESRD).

At a glance

Mechanism of action

Physioneal 35 is a bicarbonate-buffered peritoneal dialysis solution designed to improve biocompatibility compared to conventional lactate-buffered solutions. It contains a physiologic electrolyte composition and uses bicarbonate as the primary buffer, which reduces glucose degradation products and advanced glycation end products (AGEs) that can damage the peritoneal membrane. This formulation aims to preserve peritoneal function and reduce inflammation during long-term peritoneal dialysis treatment.

Approved indications

• Peritoneal dialysis in end-stage renal disease (ESRD)

Common side effects

• Peritonitis
• Hyperglycemia
• Electrolyte imbalances
• Abdominal discomfort

Key clinical trials

• Efficacy and Safety of XyloCore Peritoneal Dialysis Solution. (PHASE3)
• IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients (PHASE4)
• IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients (PHASE3)
• Randomized Multicenter Cross-over Study to Compare the Effect of Physioneal 35 to 40 on the Protein Metabolism (PHASE4)

Primary sources

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